Familial Thyroxine-Binding Globulin Deficiency Associated with Hyperthyroidism.

Familial thyroxine-binding globulin deficiency.

Genetically determined thyroxine-binding globulin deficiency is described in two families in the United Kingdom. All subjects in both pedigrees were euthyroid. Transmission was by sex-linkage; males showed low serum protein bound iodine and high thyroxine (T4) resin uptake due to complete absence of serum thryroxine-binding globulin; females were less severely affected. The distinctive biochemi...

Growth retardation and thyroxine-binding globulin deficiency.

Familial thyroxine-binding globulin deficiency: search for linkage with Xg blood groups.

Primary thyroid failure with concomitant thyroxine binding globulin deficiency.

Thyroxine-Binding Globulin Concentrations

Plasma thyroid hormone concentrations may be abnormal in non-thyroid disease and pose diagnostic problems. For example, concentrations of triiodothyronine (T3) in the blood decline in acute illness with a reciprocal increase in reverse triiodothyronine (reverse T3), but thyroxine (T4) concentrations are usually normal or only slightly decreased (1, 2). However, McLarty et al. (3) reported that ...